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Event Scheduled for Oct 30, 2018


Event: MSE PhD Dissertation Proposal - Le Yu (Jasper)

Location: IMS-101B

Time: 02:00 pm

Details of Event:
MSE PhD Dissertation Proposal

Presenter: Le Yu (Jasper)
Major Advisor: Dr. Mei Wei
Associate Advisors: Dr. Mark Aindow, Dr. Xiuling Lu

Date: Tuesday, October 30th, 2018
Time: 2:00 PM
Place: IMS 101B

Title: Preparation and Characterization of Collagen-Hydroxyapatite Composites for Biomedical Applications

Collagen, the most abundant protein, and hydroxyapatite, the main component in natural bone, are usually used as a biomimetic composite material in many biomedical applications due to its excellent biocompatibility and biodegradability. In this dissertation study, a trail is making to systematically design, develop and characterize collagen-hydroxyapatite (Col-HA) composite materials and further explore their wide biomedical applications. Firstly, collagen-based nanoworms with different sizes were self-assembled from collagen triple helices by precisely controlling the polymerization process of collagen molecules to be used as long circulation drug delivery vehicles on tumor therapy application. Intrafibrillar mineralized Col-HA nanoworms were then developed based on this to increase the stiffness and surface property of collagen. As a result, the mineralized Col-HA nanoworms demonstrated significantly prolonged blood circulation time, which is one of the most important factors influencing the therapy efficacy of drug delivery platforms. Secondly, the intrafibrillar mineralization degree of Col-HA fibrils was enhanced by the employing of carboxyl-rich brushlike polymers, which is believed to be capable of replicating the sequestration functions of non-collagenous proteins (NCPs) that regulating collagen mineralization. This enriches the application of Col-HA composite by providing the possibility to adjust the mineral content to be rigid as a bone, compliant as a tendon, or have a gradient from rigid to compliant as a cartilage. Thirdly, two essential elements, Fe and Mn, were substituted into intrafibrillar mineralized Col-HA scaffolds to improve the osteogenic ability of the material. This provides a meaningful strategy to create smart Col-HA-based scaffolds for bone tissue repair. Lastly, a Col-HA composite coating was fabricated in a single one-step biomimetic process on Ti-6Al-4V, the most widely used titanium alloy, to grant the inert substrate with bioactivity. The cross-sectional characteristics of the coating were thoroughly investigated and reconstructed in 3D using focused ion beam (FIB) to get better idea on the mechanical property and biocompatibility affected by its microstructure. As such, the remaining work of this dissertation will be focused on: (i) in vivo drug loading, releasing, surface modification and tumor therapy efficacy investigation of the mineralized Col-HA nanoworms; (ii) in vitro and in vivo osteogenesis evaluations of the Fe/Mn-bearing Col-HA scaffolds; (iii) nanoscale FIB observation and 3D reconstruction bone mineral that newly formed within the scaffolds post-implantation; (iv) nanoscale mechanical test on the Col-HA composite coating.

Keywords: Col-HA composite, nanoworms, drug delivery, tissue engineering, osteogenesis, coating, characterization, FIB

Target Audience: Not Available

Sponsored By: Materials Science and Engineering Program

Pamphlet/Flyer: No Pamphlet/Flyer Available

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