Biomolecular Nanoengineering Laboratory
 


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Education

May  2004      Ph.D. in Biomedical Engineering

                      Certificate in Biomolecular & Tissue Engineering

 Duke University, Department of Biomedical Engineering, Durham, NC

 Advisor:Dr. Fan Yuan ;Co-advisor: Dr. Chuan-Yuan Li 

June 1998      M.S. in Chemical Engineering

 Chinese Academy of Sciences, Dalian Institute of Chemical Physics, Dalian, China

 Advisor: Prof. Xiaojun Ma

June 1995      B.S. in Environmental Chemistry

 Jilin University, Department of Environmental Sciences, Changchun, China

 Advisor: Prof. Zongmu Wang

Employments

2006 – present Assistant Professor, UConn, School of Engineering

                        Programs of Chemical & Biomolecular Engineering and Biomedical Engineering

2004 – 2006    Research Associate (Advisors: Drs. Eli Gilboa and Bruce Sullenger)

Duke University, Translational Research Institute

1998 - 1999     Research Assistant (Advisor: Prof. Xiaojun Ma)

               Chinese Academy of Sciences, Dalian Institute of Chemical Physics

Research Interests

Nanobiotechnology

Therapeutic & Diagnostic Nanomedicines

Human Embryonic Stem cells & Tissue Engineering

Grants, Awards, Honors and Research Recognitions

2007-2010        DMR grant                                  Naional Science Foundation (PI)

2007-2008        Faculty Large Research Grant   UConn Research Foundation (PI)

2006-present    Full Member                                Biomedical Engineering Society

  • The study on RNA nanomedicine was highlighted:

Nature Biotechnology (2006; 24: 951-952)

Molecular Therapy (2006; 14 (4): 461-462)

  • The studies on the delivery of gene nanomedicines were highlighted:

Gene Therapy (2006; 13: 1131-1132);

Nature Clinical Practice Oncology ((2005) 2, 603-604);

Trends in Biotechnology (2004 Mar; 22(3):101-103);

ScienceDaily News (http://www.sciencedaily.com/releases/2005/11/051121103141.htm);

Star Weekend Magazine (http://www.thedailystar.net/magazine/2005/12/02/scitech.htm);

Medical News Today (http://medicalnewstoday.com/medicalnews.php?newsid=33940);

......

       

 Committes and Journal Service

2006-present        Graduate Admissions Committee
2006-present        Faculty Search Committee

Guest Editor:         IEEE Engineering in Medicine and Biology

Journal Reviewer: Cancer Research

         British Journal of Cancer

         International Journal of Pharmaceutics

         AAPS PharmSciTech

         Gene Therapy

         Biotechnology Progress

         Applied Microbiology and Biotechnology
         Journal of Biomedical Materials Research: Part A

Publications since 08/2006

Editorial Material

  1. Wang Y. Engineering strategies for drug delivery. IEEE Engineering in Medicine and Biology. In Press.

Peer-Reviewed Journal Papers

  1. Zhou J, Xu RH, and Wang Y.  Nanoporous membrane-encapsulated feeder cells for culture of human embryonic stem cells. International Journal of Functional Informatics and Personalized Medicine. Accepted
  2. Zhou J, Soontornworajit B, Sullenger BA, Gilboa E, Wang Y. Hybrid DNA aptamer-dendrimer nanomaterials for targeted cell binding.  Under review.
  3. Lin CW, Wang Y, Challa P, Epstein DL and Yuan F. Transscleral diffusion of ethacrynic acid and sodium fluorescein. Journal of Molecular Vision. 2007; 13: 243-251 .
  4. McNamara II JO*, Andrechek ER*, Wang Y, Viles KD, Rempel RE, Gilboa E, Sullenger BA, Giangrande PH. Cell-type specific delivery of siRNA with aptamer-siRNA chimeras. Nature Biotechnology. 2006; 24(8) 1005-1015. (*equally contributed) (Highlighted: Nature Biotechnology, Molecular Therapy,   etc.).

Publications before 08/2006

  1. Wang Y and Yuan F. Delivery of viral vectors to tumor cells: Extracellular transport, systemic distribution, and strategies for improvement. Annals of Biomedical Engineering. 2006; 34(1): 114-127.  (Invited; special issue: Nanobioengieering).
  2. Wang Y, Wang H, Li CY and Yuan F. Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery. Molecular Cancer Therapeutics. 2006; 5(2):362-366.
  3. Wang Y*, Chen Q* and Yuan F. Alginate encapsulation is a highly reproducible method for tumor cell implantation in dorsal skinfold chamber. Biotechniques. 2005; 39(6): 834-838. (*equally contributed)
  4. Wang Y, Liu S, Li CY and Yuan F. A novel method for viral gene delivery in solid tumors. Cancer Research. 2005; 65(17):7541-7545 (Highlighted: Nature Clinical Practice Oncology, Gene Therapy, Medical News Today, etc.).
  5. Wang Y, Yang Z, Liu S, Kon T, Li CY and Yuan F. Characterization of systemic dissemination of non-replicating adenoviral vectors from tumors in gene delivery. British Journal of Cancer 2005; 92 (8): 1414-1420
  6. Wang Y, Challa P, Epstein DL and Yuan F. Controlled release of ethacrynic acid from poly (lactide-co-glycolide) films for glaucoma treatment. Biomaterials. 2004; 25(18): 4279-85
  7. Wang Y, Hu JK, Krol A, Li YP, Li CY and Yuan F. Systemic dissemination of viral vectors during intratumoral injection. Molecular Cancer Therapeutics. 2003; 2: 1233-1242 (Highlighted: Trends in Biotechnology, ScienceDaily News, Innovation Report, etc.)
  8. He Y, Xie YB, Wang Y, Liu Q and Ma XJ. Improved Mathematical Model of APA Microcapsules. Chemical Journal of Chinese Universities. 2000; 21(2): 278-282 
  9. Wang Y, He Y, Liu Q, Li J and Ma XJ. Deacetylation of chitosan films. Chemical Journal on Internet. http://www.chemistrymag.org//cji/2000/02b051ne.htm  
  10. Wang Y, Li M and Ma XJ. Influence of reaction time on the preparation of alginate/chitosan microcapsule. Chemical Journal on Internet. Http://china.chemistrymag.org/col/1999/c99060.htm 
  11. Wang Y, Xie YB and Ma XJ. Progress of studying alginate/chitosan microcapsules. Progress of Bioengineering. 1999; 19 (2), 13-20  

Book Chapter

  1. Ma XJ, Xie YB and Wang Y. Controlled release and microcapsule membranes. In Handbook of Membrane Technology and Science. Editors: Shi J, Yuan Q and Gao C, Chemical Industry Press, Beijing, 2001; p 807-827.

Patent

  1. Yuan F, Wang Y and Li CY. Methods and compositions for reducing systemic toxicity of viral vectors (PCT/US2006/005044; US 60/652,171)

        Selected Papers/Abstracts in Conference Proceedings

  • Yuan F and Wang Y. Systemic dissemination of viral vectors during and after intratumoral infusion. BMES Meeting, Sep. 28-Oct. 1, 2005. Baltimore, MD. Abstract No. 142109.

  • Wang Y, Li CY and Yuan F. Systemic virus dissemination during local gene delivery in solid tumors and its control with an alginate solution. Proceedings of the 26th Annual International Conference of The IEEE EMBS, Sep. 1-5, 2004. San Francisco, CA. p3524-3526.

  • Wang Y, Li CY and Yuan F. Adenovirus dissemination in convection-enhanced delivery and its control with a polymeric vehicle. The 226th ACS National Meeting, Sep.7-11, 2003. New York, NY. Abstract No. 668381.

  • Yuan F and Wang Y. Controlled release of ethacrynic acid from PLGA films for glaucoma treatment. AICHE 2002 Annual Meeting. Nov.3-8, 2002. Indianapolis, IN.  Abstract No. 307a.

  • Cheng-Wen Lin, Yong Wang and Fan Yuan. Transscleral diffusion of ethacrynic acid and sodium fluorescein. Proceedings of the Second Joint EMBS-BMES Conference. October 23-26, 2002. Huston, TX. p515.

  • Wang Y, Hu JK, Krol A, Li YP, Li CY and Yuan F. Reducing systemic toxicity in local tumor gene therapy using an alginate solution. Proceedings of the Second Joint EMBS-BMES Conference. October 23-26, 2002. Huston, TX. p565.