Mechanical analysis of microtissues


We use micromechanical chop-sticks to characterize mechanical properties of microtissues. We have quantified the elastic moduli of cancer spheroids for the first time to our knowledge!

  • Jaiswal et al. PLoS ONE 12, e0188346, 2017. link


We can measure the stiffness of microtissues sized ~100 micrometer to 1 mm. We are open to collaboration. If you are interested in the study, pleaes contact the PI.

For details of the ongoing projects, visit: Cloud Micro


Detection and characterization of cancer cells


We have developed a microfluidic system that successfully separated cancer cells from clinical blood samples of patients with breast, prostate, colon, and lung cancer.

  • Hoshino et al. Lab on a Chip 11, 3449-3457, 2011.
  • Hoshino et al. Analytical Chemistry, 84, 4292-4299, 2012.
  • Huang et al. Biomedical Microdevices, 15, 673-681, 2013.
  • Chen et al. Lab on a Chip, 14, 446-458, 2014.
  • Chen et al. Scientific Reports, 5, 8745, 2015.

Micromechanical probe-based optial imaging and force sensing


We integrate new functionalities onto silicon probes for optical microscopy. Photograph shows an example of integrated quantum dot (QD)-based nanoscale LEDs integrated at the tip of near field scanning optical microscopy probe.

  • Hoshino et al., Applied Physics Letters, 101, 043118, 2012.
  • Hoshino et al., Langmuir 2008, 24, 13804-13808.
  • Hoshino et al., IEEE Journal of Microelectromechanical Systems 17, 4-10, 2008.
  • Hoshino et al., Applied Physics Letters, 92, 131106, 2008.
  • Gopal et al., Biomedical Microdevices, 10, 611-622, 2008
  • Onoe et al., Langmuir 21, 11251-11261, 2005.

Micromechanical Scanners


Microfabricated mechanical scanners are strong tools for optical microscopy, image sensors, and displays. We have utilized silicon microscanners for hand-held confocal miscopy, optical coherence tomography (OCT), compound eye-shaped robot vision system, and ultra-resolution full color displays. The image is a 2D nanopositioning scanncer made of 3D printed titanium flexure.

  • Fiaz et al., Sensors and Actuators A, 249, 284-293, 2016
  • Kumar et al., Journal of Optics A: Pure and Applied Optics, 10, 044013, 2008.
  • Kumar et al., Biomedical Microdevices 10:653-660, 2008.
  • Hoshino et al., IOP Journal of Micromechanics and Microengineering, 15, 2194-2197, 2005.

Hyperspectral imaging


The Use of colloidal quantum dots (QDs) allows for creation of compact, multi-color light sources for hyper spectral imaging.

  • Hoshino et al., Biomedical Optics Express, 5, 1610-1615, 2014.
  • Hoshino et al., Sensors and Actuators A, 216, 301-307, 2014
  • Gopal et al., Applied Physics Letters, 96, 131109, 2010.
  • Gopal et al., Nanotechnology 20, 235201, 2009.
  • Cloud Microscopy

Our current micropalpation research includes the facility to observe and manipulate our microscopes remotely. Depending on the current state of our research, camera may not be availible. To view, visit: Cloud Micro

Biomedical Engineering Department
School of Engineering
University of Connecticut