Event Scheduled for Nov 29, 2017
Event: MSE PhD Dissertation Proposal - Kenneth S. Ogueri
Time: 10:00 am
Details of Event:
PhD Dissertation Proposal
Presenter: Kenneth S. Ogueri
Major Advisor: Dr. Cato T. Laurencin
Associate Advisors: Dr. Lakshmi S. Nair, Dr. Harry R. Allcock, Dr. Thanh D. Nguyen, Dr. Jorge L. Escobar Ivirico
Date: Tuesday, December 5, 2017
Time: 1:00 pm
Room: L5053, UCONN Health Center
Title: Design and Development of Novel Biocompatible and Mechanically Competent Polyphosphazene-based Blends for Bone Tissue Regeneration
Musculoskeletal tissue loss or failure is one of the most devastating and costly problems in human health care. It has witnessed a tremendous increase in recent years. A variety of musculoskeletal diseases including back pain, arthritis, osteoporosis, and bodily injuries are now a common trend. However, the emergence of regenerative engineering offers a new strategy for addressing this challenging issue.
Regenerative engineering presents a tool that combines the fields of advanced materials science, stem cell science, physics, developmental biology and clinical translation for the common goal of regenerating complex tissues and biological systems such as a knee or a whole limb. Biomaterials play an important role in the success of this new approach as temporary supportive substrates. An ideal biomaterial for regenerative engineering should be biocompatible, have desired initial mechanical properties, should degrade in a controlled fashion timed to match the rate of tissue regeneration, have resorbable degradation products, present interconnected porous structures, be osteoconductive and allow for neovascularization. However, so far a biomaterial that can match all the properties listed above has not been developed.
Polyphosphazenes offer an ideal platform for the design and synthesis of novel biodegradable polymeric biomaterials with efficient control over degradation rate, mechanical properties, In vitro osteocompatibility, and In vivo biocompatibility.
Four specific aims are proposed to design and develop high strength dipeptide-based polyphosphazene-PLAGA blend materials. The main goal is to develop blend systems with high mechanical strength as close as polyetheretherketone (PEEK), however degradable with unique inherent pore forming properties upon degradation.
Results so far, show that optimizing the side group chemistry of polyphosphazenes can yield polymers with high glass transition temperatures (~108oC), low polydispersity indices (~1-3.5), and moderate molecular weights.
These novel peptide-based blend systems have the potential to form neutral pH degradation products due to the unique buffering effects of polyphosphazene degradation products. Detailed descriptions of the proposed aims are discussed.
Target Audience: Not Available
Sponsored By: Materials Science and Engineering Department
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