Event Scheduled for Feb 1, 2013
Event: BME Seminar-Real-time Interlaced Ultrasound and Photoacoustic System for In Vivo Ovarian Cancer Imaging & Single Wall Carbon Nanotube/Bis Carboxylic Acid-ICG as a Sensitive Contrast Agent for In Vivo Tumor Imaging in Photoacoustic Tomography
Location: IT 336 and Teleconferenced to UCHC Low Learning Center, Farmington
Time: 12:00 pm
Details of Event:
Presenter: Umar Alqasemi, PhD Student, BME
Title: Real-time Interlaced Ultrasound and Photoacoustic System for In Vivo Ovarian Cancer Imaging
In this presentation, we report an ultrafast co-registered ultrasound and photoacoustic imaging (PAT) system based on FPGA parallel processing. The system features 128-channel parallel acquisition and digitization, along with FPGA-based reconfigurable processing for real-time co-registered imaging of up to 15 frames per second limited by the laser pulse repetition frequency. We demonstrate the imaging capability of the system with a compact transvaginal ultrasound probe that includes the PAT illumination using an optic fiber assembly. The system has the ability to assist a clinician to perform transvaginal ultrasound scanning and to localize an ovarian mass, while simultaneously map the absorption of the ultrasound detected mass to reveal its vasculature using the co-registered PAT. The imaging capability of the system is demonstrated with in vivo mice tumor models.
Presenter: Saeid Zanganeh, Ph.D. Student, BME
Title: Single Wall Carbon Nanotube/Bis Carboxylic Acid-ICG as a Sensitive Contrast Agent for In Vivo Tumor Imaging in Photoacoustic Tomography
In the near-infrared wavelengths, the light absorption of the blood, the natural photoacoustic source is low. To enhance the photoacoustic signal detection of deeper structures or targets, contrast agents are needed. Contrast agents in general must be biocompatible and highly specific to the disease. For photoacoustic imaging (PAT), they must have high absorption coefficients. In this study, we present a novel photoacoustic contrast agent which is based on bis-carboxylic acid derivative of Indocyanine green (ICG) covalently conjugated to single-wall carbon nanotubes (ICG/SWCNT). Covalently attaching ICG to the functionalized SWCNT provides a more robust system that delivers much more ICG to the tumor site. The detection sensitivity of the new contrast agent in mouse tumor model is demonstrated in vivo by our custom built photoacoustic imaging system. PAT summation signal is used to show the long-lasting light absorption of tumor areas in ICG injected mice and ICG/SWCNT injected mice. It is shown that ICG is able to provide 33% enhancement at approximately 20 minutes peak response time referred to pre-injection PAT summation level, while ICG/SWCNT provides 128% enhancement at 80 minutes and even higher enhancement of 196% at the end point of experiments (120 minutes on average). Additionally, the ICG/SWCNT enhancement was mainly observed at the tumor periphery as confirmed by fluorescence images of the tumor samples. This feature is highly valuable in guiding surgeons to assess tumor boundaries and dimensions in vivo and improve surgical resection of tumors for achieving clean tumor margins.
Target Audience: Not Available
Sponsored By: Biomedical Engineering
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