Today, biological scientific research is increasingly computation driven. To ensure that the University of Connecticut is poised to both meet this need and help propel the emerging technology revolution in bioinformatics, the School of Engineering established the Bioinformatics and Biocomputing Institute (BIBCI) in 2003. It is BIBCI’s mission to serve as a nexus of collaborative, multi-disciplinary activities among biological and biomedical scientists and computational scientists. As a core computing facility dedicated to bioinformatics computing, BIBCI is critical in advancing collaborative research goals among a wide variety of computation-intensive biological research that will benefit the state and nation.