Event Scheduled for Dec 11, 2017
Event: MSE PhD Dissertation Defense - Changmin Hu
Time: 10:00 am
Details of Event:
PhD Dissertation Defense
Presenter: Changmin Hu
Major Advisor: Dr. Mei Wei
Associate Advisors: Dr. Mark Aindow and Dr. Yu Lei
Advisory Committee: Dr. Montgomery T. Shaw and Dr. Seok-Woo Lee
Date: Monday, December 11th, 2017
Time: 10:00 am
Title: Fabrication and Characterization of Collagen-Apatite Composites for Bone Tissue Engineering
Abstract: Due to the high demand of scaffolds for treating bone fractures every year, biomimetic coatings and scaffolds resembling the composition and structure of natural bone are of keen interest of bone tissue engineerers. In this research, a series of biomimetic coatings and scaffolds have been developed, including biomimetic apatite coatings, collagen-apatite coatings, intrafibrillar calcified collagen fibrils, intrafibrillar silicified collagen fibrils, and intrafibrillar calcified collagen scaffolds.
Cross-sectional SEM images and TEM images revealed that crack-free biomimetic coatings have been achieved by adjusting the pH of the m-SBF. The coating formed demonstrates a gradient porous structure, which is dense close to the substrate and then it becomes more and more porous towards the surface of the coating.
Biomimetic collagen/apatite scaffolds consisting of intrafibrillar mineralized collagen fibrils were prepared via a bottom-up approach, resembling the composition and structure of natural bone from the nanoscale to the macroscale. At the macro-scale, unidirectional macro-pores are aligned across the entire scaffold, and at the micro-scale, each layer is comprised of aligned and well stacked lamella. Finally, at the nano-scale, apatite minerals deposited within the gap zone of collagen fibrils and oriented along the long axis of these fibrils. The biomimetic collagen-apatite scaffolds demonstrated a good biocompatibility in vitro, indicating a great potential to be used for bone tissue engineering applications.
Target Audience: Not Available
Sponsored By: Materials Science and Engineering Program
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